Penn State vs. Indiana Odds, Picks, Betting Prediction

penn state indiana betting picks

Nittany Lions football is back, so let’s jump into how to bet on the season opener with our Penn State vs. Indiana betting preview with odds, picks, and predictions.

After a delay to its season due to the lingering COVID-19 pandemic, the Big Ten schedule finally kicks off on Saturday and bettors in Pennsylvania and Indiana should be fired up for this one. And in the opening week of action, the No. 8-ranked Penn State Nittany Lions go on the road to face the Indiana Hoosiers.

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Of course, this is a sight to see regardless of who’s playing. Amid the pandemic, the Big Ten originally canceled its 2020 season but has since reversed that decision. Although a compressed 2020 campaign, college football fans (and football fans in general) we’ll take anything they can get during these difficult times.

While the Hoosiers are coming off a 2019 season in which they finished 8-5 and lost in the Gator Bowl by one to Tennessee, the Nittany Lions were 11-2 and emerged victorious in the Cotton Bowl by a score of 53-39 over Memphis.

DraftKings Sportsbook

States: PA, NJ, IN, IL, CO, WV


Penn State vs. Indiana Betting Line

Given their historical head-to-head dominance in this series, Penn State enters this contest as a fairly modest 6.5-point favorite. Here’s a look at the current Penn State vs. Indiana odds, courtesy of DraftKings Sportsbook:

          Spread     Moneyline 
Penn State     -6.5 (-110)   -250   O 62 (-110)
Indiana      +6.5 (-110)    +170   U 62 (-110)


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Sure the first game of the season is when many questions are answered for either program, but as far as what we currently know, Penn State is one of the top teams in the country while the opposition just can’t get over the hump.

Despite the fact that they’ll be on the road to commence the 2020 slate, Penn State should emerge victorious in this game as well as cover the spread.

The total in this game is currently sitting at 62.0, and it may be a beneficial idea to take the over. Penn State head coach James Franklin runs a successful offense that put up 35.8 points per game last year as well as gained an average of 413.3 yards. This, paired with a Tom Allen-run program that averaged 31.8 points and 433.2 yards in 2019 should lead to a high-scoring matchup that could very easily surpass 62 points.

penn state indiana betting

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Penn State vs. Indiana Betting Preview

Penn State enters this game having undergone a successful 2019 campaign in which it finished 11-2 (7-2 in the Big Ten). Notable wins took place over Iowa, Michigan, as well as Indiana, who was the No. 24-ranked team in the country by the time the game occurred.

It all led to a big win over Memphis in the Cotton Bowl, where Penn State ousted the Memphis Tigers by a score of 53-39 behind 202 rushing yards and two touchdowns from running back Journey Brown. Wideout Jahan Dotson additionally caught a touchdown pass for the Nittany Lions in that very matchup.

The Nittany Lions may have to proceed without Brown though, as the 21-year-old could miss the entirety of the campaign due to an undisclosed medical condition. This means Noah Cain may have to take the bulk of the load after rushing for 443 yards and eight touchdowns last year.

Indiana, on the other hand, was 8-5 last year but 0-4 against ranked teams. The Hoosiers came up short against Penn State, Ohio State, Michigan, and Michigan State last year, with the additional loss coming at the hands of Tennessee in the Gator Bowl.

While the Hoosiers have lost 2019 starting quarterback Peyton Ramsey, they’ll be returning their leading rusher from a year ago in running back Stevie Scott. The Syracuse native rushed for 845 yards and 10 touchdowns last season on a 4.7 yards-per-carry rate, additionally catching 26 passes for 211 yards and one score through the air.

In addition, Indiana returns its 2019 leading receiver in Whop Philyor, who caught 70 balls for 1,002 yards and five touchdowns last year, sitting atop the roster in each of the aforementioned categories.

It’s tough to tell how dominant either program will be considering neither has played a game since December or January, but there’s certainly talent within either offensive unit, which should make for an entertaining 60-minute battle.

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FanDuel Sportsbook

States: PA, NJ, IL, CO, IN, TN, WV


Penn State vs. Indiana Historical Matchup Stats

Penn State has won each of the last five meetings outright, but the team who covers the spread has actually gone back and forth. During last year’s meeting, the Nittany Lions emerged victorious by a score of 34-27, but Indiana was a 15-point underdog. The over (55.0) additionally hit.

Indiana covered in 2018 as well, entering as a 14-point underdog but losing by five. The over (58.5) also hit in that game.

Penn State covered in 2017, 2016, and 2015 though, entering as a big favorite (-18.5) in the 2017 matchup and proving the oddsmakers correct with a 45-14 victory (under-61.5).

How to Watch Indiana-Penn State

  • Date: Saturday, Oct. 24
  • Time: 3:30 p.m. ET
  • Location: Memorial Stadium (Bloomington, IN)
  • TV: FS1

Penn State vs. Indiana Betting Picks and Score Prediction

As was previously mentioned, Indiana is a decent program, but Penn State is just too talented and will possess the edge on either side of the ball. While the Nittany Lions will cover the 6-point spread and win the game outright, the over will additionally hit, considering these two programs should carry over the successful offensive systems they employed in 2019.


We’re rolling with the over and Penn State to cover by a 42-28 final.

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DraftKings Sportsbook

States: PA, NJ, IN, IL, CO, WV

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